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Mechanistic research exposed compound 48 induced S-stage cell cycle arrest and apoptosis in CCRF-CEM cells. The composition–activity connection (SAR) analysis indicated that a five,six-dimethoxy moiety plus a 2-ethyl ester team about the indole scaffold ended up essential for great antiproliferative potency, highlighting the opportunity of such d
After the completion from the reaction, the solvent was evaporated beneath lowered pressure to get the corresponding imine products, which was further used in the subsequent phase devoid of prior purification., OCH3) teams was subjected to response with 1a beneath the optimized problems; 3d was afforded in a little decrease (seventy eight%) produce
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